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Haytham Ahmed Zakai
Document Details
Document Type
:
Article In Journal
Document Title
:
Effect of itraconazole and terbinafine on leishmania promastigotes
تاثير عقاري اتراكونازول وتيربينافين على الطور السوطي لطفيل الليشمانيا
Subject
:
Leishmania
Document Language
:
English
Abstract
:
The antiproliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major, L. donovani and L. mexicana promastigotes are reported. Treatment of promastigotes cultures with itraconazole or with terbinafine induced growth arrest with L. major but neither with L. donovani nor with L. mexicana. Concentrations of 0.75 microl/l or more of itraconazole induced cell lysis after 72 hours with L. major. However, even relatively large concentrations of terbinafine (2.0 microl/l) did not induce cell lysis. For L. major, the IC 50 for itraconazole and terbinafine were 0.31 microl/l and 3.3 microl/l respectively.
ISSN
:
1110-0583
Journal Name
:
Journal of the Egyptian Society for Parasitology
Volume
:
33
Issue Number
:
1
Publishing Year
:
1423 AH
2003 AD
Article Type
:
Article
Added Date
:
Sunday, October 26, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
هيثم أحمد زكائي
Zakai, Haytham Ahmed
Investigator
Doctorate
hzakai@kau.edu.sa
سمير خضر زمو
Zimmo, Sameer Khedr
Researcher
Doctorate
محمود فؤاد
Fuoad, Mahmoud
Researcher
Doctorate
Files
File Name
Type
Description
18320.pdf
pdf
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